Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise
نویسندگان
چکیده
منابع مشابه
Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise.
BACKGROUND Nitric oxide (NO) causes vasodilation by stimulation of guanylate cyclase in vascular smooth muscle to produce cGMP. The resultant vasodilator effect is regulated by a family of cGMP phosphodiesterases (PDEs). Sildenafil, a selective inhibitor of PDE5 used for treatment of erectile dysfunction, has been found to cause relaxation of isolated epicardial coronary artery segments. The pr...
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PDEs belong to a large superfamily [11 different gene families (PDEs 1–11)] of structurally related, functionally distinct, and highly regulated enzymes (Francis et al., 2001). Most PDE families comprise more than one gene ( 20 PDE genes), which generate multiple protein products ( 50 PDE proteins) via alternative mRNA splicing or use of different promoters/transcription initiation sites. Most ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2000
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.102.24.2997